Unit of Neurology, Dept of Clinical Medicine, Ospedale di Circolo - University of Insubria, Varese, Italy.
Neuropsychiatr Dis Treat. 2008 Dec;4(6):1267-71. doi: 10.2147/ndt.s4288.
Mild parkinsonian signs (MPS) may be found among patients presenting with mild cognitive impairment (MCI), but few data are available about the relation of these signs with the prospective risk for dementia. Our retrospective investigation considered a case-series of 119 MCI subjects followed over a three-year period: their baseline clinical picture has been analyzed in search of correlation between the cognito-motor profile and the final diagnosis. The population included 66 patients with amnesic MCI and 53 with an involvement of other cognitive areas (nonamnesic MCI). MPS were detected in 22 subjects (18.5%). At the first observation, MPS cases showed an higher frequency of nonamnesic MCI and more pronounced deficits at the Trail Making Test (p < 0.05). After a three-year follow-up, 48 patients had converted to dementia. The presence of MPS at the baseline evaluation was significantly related to the development of a vascular-type dementia. The study investigates the association between MPS and MCI and might indicate for these cases a greater risk for an involvement of executive functions and the subsequent development of vascular dementia.
轻度帕金森病征象（MPS）可能出现在出现轻度认知障碍（MCI）的患者中，但关于这些征象与痴呆的未来风险之间的关系的数据很少。我们的回顾性研究考虑了一个由 119 名 MCI 患者组成的病例系列，这些患者在三年内接受了随访：分析了他们的基线临床情况，以寻找认知运动特征与最终诊断之间的相关性。该人群包括 66 名有记忆障碍的 MCI 患者和 53 名有其他认知区域受累的患者（非记忆障碍的 MCI）。22 名患者（18.5%）出现 MPS。在第一次观察时，MPS 病例表现出非记忆障碍 MCI 的更高频率和更明显的 Trail Making Test 缺陷（p<0.05）。经过三年的随访，48 名患者转为痴呆。基线评估时存在 MPS 与血管性痴呆的发展显著相关。该研究调查了 MPS 与 MCI 之间的关联，并可能表明这些病例的执行功能受累风险更高，随后发展为血管性痴呆的风险更高。
