Park Ji-Hyun, Lee Young-Chun, Lee Se-Youp
Department of Ophthalmology, College of Medicine, Keimyung University of Korea, Daegu, Korea.
Korean J Ophthalmol. 2009 Mar;23(1):40-2. doi: 10.3341/kjo.2009.23.1.40. Epub 2009 Mar 9.
To maximize effective use of mydriatic drugs through comparing the pupillary dilation effects between 1% tropicamide and 2.5% phenylephrine.
Fifty people requiring pupillary dilation were divided into 3 groups. Group 1 was treated with one drop of 1% tropicamide in the right eye and one drop of 2.5% phenylephrine in the left eye. Group 2 was treated twice during a 5-minute interval with 1% tropicamide in the right eye. Group 3 was treated twice during a 5-minute interval with 2.5% phenylephrine in the right eye. Groups 2 and 3 were treated with 2.5% phenylephrine and 1% tropicamide in the left eye, administered during a 5-minute interval. The pupillary size was measured in all groups for 40 minutes following eye drops administration.
The mean patient age was 15.7 years. Group 1 included 10 patients, and groups 2 and 3 included 20 patients each. Eight patients in group 1 and 16 patients in group 2 developed a larger right pupil. Fourteen patients in group 3 developed a larger left pupil.
Our study showed that 1% tropicamide, with its parasympathetic antagonistic mechanism of action, was more effective at inducing pupillary dilation than 2.5% phenylephrine, and the combination of 1% tropicamide and 2.5% phenylephrine was more effective than multiple drops of single eye drops.
通过比较1%托吡卡胺和2.5%去氧肾上腺素的散瞳效果，最大限度地有效使用散瞳药物。
50名需要散瞳的患者被分为3组。第1组右眼滴一滴1%托吡卡胺，左眼滴一滴2.5%去氧肾上腺素。第2组右眼在5分钟间隔内滴两次1%托吡卡胺。第3组右眼在5分钟间隔内滴两次2.5%去氧肾上腺素。第2组和第3组左眼在5分钟间隔内分别滴2.5%去氧肾上腺素和1%托吡卡胺。滴眼药水后40分钟测量所有组的瞳孔大小。
患者平均年龄为15.7岁。第1组包括10名患者，第2组和第3组各包括20名患者。第1组8名患者和第2组16名患者右眼瞳孔较大。第3组14名患者左眼瞳孔较大。
我们的研究表明，1%托吡卡胺因其副交感神经拮抗作用机制，在诱导瞳孔扩张方面比2.5%去氧肾上腺素更有效，且1%托吡卡胺和2.5%去氧肾上腺素联合使用比单眼多次滴眼药水更有效。
