癌症与衰老生物学

Biology of cancer and aging.

作者信息

Holmes F F, Wilson J, Blesch K S, Kaesberg P R, Miller R, Sprott R

机构信息

University of Kansas Medical Center, Kansas City 66103.

出版信息

Cancer. 1991 Dec 1;68(11 Suppl):2525-6. doi: 10.1002/1097-0142(19911201)68:11+<2525::aid-cncr2820681508>3.0.co;2-3.

DOI:10.1002/1097-0142(19911201)68:11+<2525::aid-cncr2820681508>3.0.co;2-3

PMID:1933796

Abstract

The greatest risk factor for cancer is aging. Human cancer incidence increases exponentially with advancing age. Cancer growth rate and potential for metastatic spread may be influenced by age-specific change in host response. Because cancer and aging are, thus, inextricably linked, the American Cancer Society should encourage submission of research proposals that address the mechanisms of aging and how aging alters cancer development.

摘要

癌症最大的风险因素是衰老。人类癌症发病率随年龄增长呈指数上升。癌症的生长速度和转移扩散的可能性可能受宿主反应中特定年龄变化的影响。因此，由于癌症与衰老有着千丝万缕的联系，美国癌症协会应鼓励提交探讨衰老机制以及衰老如何改变癌症发展的研究提案。