Nativ O, Reiman H M, Lieber M M, Zincke H
Department of Urology, Mayo Clinic, Rochester, Minnesota 55905.
Cancer. 1991 Dec 15;68(12):2575-8. doi: 10.1002/1097-0142(19911215)68:12<2575::aid-cncr2820681208>3.0.co;2-v.
Forty-six patients with primary squamous cell carcinoma of the upper urinary tract treated over a 44-year period were studied. The lack of characteristic presentation caused delay in diagnosis. Associated urinary calculi were found in only five (11%) of the patients. Almost all of the tumors were histologically high grade; at surgery, 84% of the tumors were locally advanced or metastatic. Prognosis is poor independent of treatment; the overall 24-month survival rate was 22%. Comparison with a previous study of renal pelvic transitional cell carcinoma indicates that these two forms of urothelial neoplasm are biologically different.
