Ozdamar A S, Ozkürkcügil C, Gültekin Y, Gökalp A
Department of Urology, Kocaeli University Hospital, Turkey.
Int Urol Nephrol. 1997;29(4):415-20. doi: 10.1007/BF02551106.
Physical traumas have been implicated as intrinsic risk factors for the progression of urothelial tumours. In stone disease, histologic changes of the urothelium have a wide spectrum. We want to show the importance of biopsies for identification of these changes. In this study, we investigated the histologic changes of the urothelium in stone patients. There were 16 squamous metaplasia, 14 pyelitis follicularis, 5 pyelitis or ureteritis cystica, 4 polypoid pyelitis or ureteritis, 2 encrusted pyelitis in 43 stone patients, and 5 calcium, 2 long-standing struvite and 2 mixed calculi histories were found in 9 of 14 upper urothelial tumour patients. According to our results, it is important to identify the histologic changes of the upper urothelium during stone surgery for possible neoplastic progression in the future. If any suspicious finding is demonstrated, the patients should be enrolled in a follow-up programme or should be transferred to tumour treatment programme. Therefore, we propose to take biopsies of the urothelium in every stone surgery.
身体创伤被认为是尿路上皮肿瘤进展的内在风险因素。在结石病中，尿路上皮的组织学变化范围广泛。我们想展示活检对于识别这些变化的重要性。在本研究中，我们调查了结石患者尿路上皮的组织学变化。43例结石患者中有16例鳞状化生、14例滤泡性肾盂炎、5例囊性肾盂炎或输尿管炎、4例息肉样肾盂炎或输尿管炎、2例结痂性肾盂炎，14例上尿路上皮肿瘤患者中有9例有5例钙结石、2例长期存在的鸟粪石结石和2例混合结石病史。根据我们的结果，在结石手术期间识别上尿路上皮的组织学变化对于未来可能的肿瘤进展很重要。如果发现任何可疑发现，患者应纳入随访计划或应转入肿瘤治疗计划。因此，我们建议在每次结石手术中对尿路上皮进行活检。
