Gershbein L L
Biochemistry and Oncology Sections, Northwest Institute for Medical Research, John F. Kennedy Health Care Corporation, Chicago, Illinois 60645.
Cancer Lett. 1991 Nov;60(2):129-33. doi: 10.1016/0304-3835(91)90219-8.
Young male Sprague-Dawley rats in 3 groups were fed a basal diet supplemented with 0.10 wt. % each of thalidomide and its imide-analog of much higher teratogenicity, EM 12. Following an induction period of 17 days on the diets, all animals were injected subcutaneously with 1,2-dimethylhydrazine at 20 mg/kg for a total of 20 weekly doses and killed on week 18 after the 20th injection. The total number of colon adenocarcinomas and their occurrence in the proximal and distal portions for the thalidomide-treated rats were similar to those of the respective controls. However, the EM 12-fed group elicited statistically significant increases both in the total and ascending colon-based adenocarcinomas as compared with the control findings, in keeping with its greater teratogenicity and embryotoxicity. The numbers of small intestinal adenocarcinomas were equally higher in the imide-fed groups in contrast to the control frequency.
将3组年轻雄性斯普拉格-道利大鼠喂食基础饮食，分别添加0.10重量%的沙利度胺及其致畸性高得多的酰亚胺类似物EM 12。在饮食诱导17天后，所有动物皮下注射20mg/kg的1,2-二甲基肼，每周注射1次，共注射20次，并在第20次注射后的第18周处死。沙利度胺处理组大鼠的结肠腺癌总数及其在近端和远端的发生率与各自对照组相似。然而，与对照组相比，喂食EM 12的组在基于全结肠和升结肠的腺癌方面均有统计学上的显著增加，这与其更高的致畸性和胚胎毒性一致。与对照组频率相比，酰亚胺喂养组的小肠腺癌数量同样更高。
