Reibnegger G, Krainer M, Herold M, Ludwig H, Wachter H, Huber H
Institute of Medical Chemistry and Biochemistry, University of Innsbruck, Austria.
Cancer Res. 1991 Dec 1;51(23 Pt 1):6250-3.
Concentrations of interleukin-6 and neopterin were measured in sera from 44 patients with multiple myeloma. To judge the relative prognostic value of these analyses, other clinical and laboratory variables were concomitantly determined. The patients were followed up to 9 years, and the abilities of all variables to predict outcome were assessed. Both neopterin (P = 0.0008) and interleukin-6 (P = 0.033) were significantly higher in patients with higher stages of the disease. The correlation between interleukin-6 and neopterin was weak but significant (Spearman's rank correlation coefficient, 0.38; P = 0.019). By univariate survival analysis using the product-limit approach, both neopterin (P = 0.0001) and interleukin-6 (P = 0.025) were identified as significant predictors of survival. Multivariate survival analyses by the proportional hazards technique demonstrated that either stage and neopterin or neopterin and interleukin-6 are useful combinations of predictor variables. Thus, interleukin-6, which is supposed to influence progression of multiple myeloma in an autocrine or paracrine manner, failed to contribute to prediction if stage was included in a model. In contrast, neopterin remained significant in all multivariate models.
检测了44例多发性骨髓瘤患者血清中的白细胞介素-6和新蝶呤浓度。为了判断这些分析的相对预后价值，同时测定了其他临床和实验室变量。对患者进行了长达9年的随访，并评估了所有变量预测预后的能力。疾病分期较高的患者，其新蝶呤（P = 0.0008）和白细胞介素-6（P = 0.033）水平均显著升高。白细胞介素-6与新蝶呤之间的相关性较弱但具有显著性（斯皮尔曼等级相关系数为0.38；P = 0.019）。采用乘积极限法进行单变量生存分析时，新蝶呤（P = 0.0001）和白细胞介素-6（P = 0.025）均被确定为生存的显著预测因子。采用比例风险技术进行多变量生存分析表明，分期与新蝶呤或新蝶呤与白细胞介素-6是预测变量的有用组合。因此，如果模型中纳入分期，以自分泌或旁分泌方式影响多发性骨髓瘤进展的白细胞介素-6对预测并无帮助。相比之下，新蝶呤在所有多变量模型中均保持显著性。
