氨氯地平衍生的酸敏感离子通道3（ASIC3）抑制剂。
Amiloride derived inhibitors of acid-sensing ion channel-3 (ASIC3).
作者信息
Kuduk Scott D, Di Marco Christina N, Chang Ronald K, Dipardo Robert M, Cook Sean P, Cato Matthew J, Jovanovska Aneta, Urban Mark O, Leitl Michael, Spencer Robert H, Kane Stefanie A, Bilodeau Mark T, Hartman George D, Bock Mark G
机构信息
Department of Medicinal Chemistry, Merck Research Laboratories, Sumneytown Pike, PO Box 4, West Point, PA 19486, USA.
出版信息
Bioorg Med Chem Lett. 2009 May 1;19(9):2514-8. doi: 10.1016/j.bmcl.2009.03.029. Epub 2009 Mar 14.
PMID:19339181
Abstract
A series of amiloride derivatives modified at the 5-position of the pyrazine ring were evaluated as inhibitors of acid-sensing ion channel-3 (ASIC3), a novel target for the treatment of chronic pain.
摘要
一系列在吡嗪环5位进行修饰的氨氯吡脒衍生物被评估作为酸敏感离子通道3（ASIC3）的抑制剂，ASIC3是治疗慢性疼痛的一个新靶点。
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