Allan R, Steinberg D M, Williams J A, Cooke W T
Gastroenterology. 1977 Oct;73(4 Pt 1):723-32.
This paper describes the clinical management of 204 patients with Crohn's disease involving the colon who have been reviewed regularly for many years. The results have been analyzed to define the morbidity, mortality, and long term prognosis of the disorder. Despite a high morbidity, the long term prognosis is good. Although the mean interval since the onset of symptoms is more than 13 years, 77% of the patients are symptom-free and 60% have normal laboratory indices. This analysis suggests that until the etiology of Crohn's disease is established and a specific therapy is developed, good results can be obtained with regular medical review and appropriate surgical treatment with the limited use of immunosuppressive agents or total parenteral nutrition.
本文描述了204例累及结肠的克罗恩病患者的临床管理情况，这些患者多年来一直接受定期复查。对结果进行了分析，以确定该疾病的发病率、死亡率和长期预后。尽管发病率很高，但长期预后良好。虽然自症状出现以来的平均间隔时间超过13年，但77%的患者无症状，60%的患者实验室指标正常。该分析表明，在克罗恩病的病因得以明确且开发出特异性治疗方法之前，通过定期医学复查以及适当的手术治疗，并有限使用免疫抑制剂或全胃肠外营养，可取得良好的效果。
