Fujinuma Y, Tanaka A, Maezawa H
Third Department of Internal Medicine, Faculty of Medicine, Tokyo Medical and Dental University.
Bull Tokyo Med Dent Univ. 1991 Sep;38(3):27-33.
The net cholesterol transfer activity from high density lipoprotein (HDL) to low density lipoprotein (LDL) was determined in the patients with coronary heart disease (CHD) to examine its effect on the pathogenesis of arteriosclerosis. Furthermore, in the CHD patients with high HDL cholesterolemia (more than 60 mg/dl), the HDL particle size was measured by high performance liquid chromatography. A significant cholesteryl ester transfer activity (P less than 0.02) was noted in the CHD patients with low HDL cholesterolemia (less than 60 mg/dl). The rate of cholesteryl ester transfer activity (cholesteryl ester transfer activity/hour) inversely correlated with the serum HDL cholesterol value (r = -0.483, P = 0.096) in the patients with CHD. These results suggest that an increase of CETA caused a low HDL cholesterol value in the CHD patients with low HDL cholesterolemia and it may have the risk of causing CHD. However, an increase of the CETA was not found in the CHD patients with high HDL cholesterolemia compared to the normal subjects, the HDL particle size being significantly greater than that in the normal subjects. In the CHD patients with high HDL cholesterolemia, the large size of HDL may have the risk of causing CHD.
测定冠心病（CHD）患者中从高密度脂蛋白（HDL）到低密度脂蛋白（LDL）的净胆固醇转移活性，以研究其对动脉粥样硬化发病机制的影响。此外，对于HDL胆固醇血症较高（超过60mg/dl）的冠心病患者，采用高效液相色谱法测量HDL颗粒大小。在HDL胆固醇血症较低（低于60mg/dl）的冠心病患者中观察到显著的胆固醇酯转移活性（P<0.02）。在冠心病患者中，胆固醇酯转移活性速率（胆固醇酯转移活性/小时）与血清HDL胆固醇值呈负相关（r=-0.483，P=0.096）。这些结果表明，在HDL胆固醇血症较低的冠心病患者中，胆固醇酯转移活性增加导致HDL胆固醇值降低，且可能有引发冠心病的风险。然而，与正常受试者相比，HDL胆固醇血症较高的冠心病患者未发现胆固醇酯转移活性增加，其HDL颗粒大小显著大于正常受试者。在HDL胆固醇血症较高的冠心病患者中，较大尺寸的HDL可能有引发冠心病的风险。
