Rakasz E, Sugar J, Csuka O
National Institute of Oncology, Budapest, Hungary.
Cancer Chemother Pharmacol. 1991;28(6):484-6. doi: 10.1007/BF00685828.
The effect of cytosine arabinoside on adenosylmethionine synthesis in relation to its proliferation-inhibiting ability was investigated in HT/29 and SW 620 human colon-tumor cell lines. A significant decrease in adenosylmethionine synthetase (E. C.2.4.2.13) activity was found after 2.5 h incubation with the drug, suggesting that depletion of adenosylmethionine pools might occur. Both this possible loss of adenosylmethionine and the cytostatic effect of cytosine arabinoside could partly be reversed by the exogenous administration of the former drug. Our data show that the cytostatic effect of cytosine arabinoside may be due in part to a shortage of adenosylmethionine; this finding is important for the design of combination chemotherapy regimens.
在HT/29和SW 620人结肠肿瘤细胞系中，研究了阿糖胞苷对腺苷甲硫氨酸合成的影响及其增殖抑制能力。用该药物孵育2.5小时后，发现腺苷甲硫氨酸合成酶（E.C.2.4.2.13）活性显著降低，提示可能发生腺苷甲硫氨酸池耗竭。外源性给予前者药物可部分逆转腺苷甲硫氨酸的这种可能损失以及阿糖胞苷的细胞生长抑制作用。我们的数据表明，阿糖胞苷的细胞生长抑制作用可能部分归因于腺苷甲硫氨酸的短缺；这一发现对联合化疗方案的设计具有重要意义。
