一种耐热古菌S-腺苷甲硫氨酸合成酶：一种用于改善具有生物技术应用价值的腺苷甲硫氨酸类似物合成的有前景的工具。
A thermostable archaeal S-adenosylmethionine synthetase: a promising tool to improve the synthesis of adenosylmethionine analogs of biotechnological interest.
作者信息
Porcelli Marina, Ilisso Concetta Paola, Mosca Laura, Cacciapuoti Giovanna
机构信息
a Dipartimento di Biochimica; Biofisica e Patologia Generale ; Seconda Università di Napoli ; Napoli , Italy.
出版信息
Bioengineered. 2015;6(3):184-6. doi: 10.1080/21655979.2015.1045170.
Abstract
The naturally and widely occurring sulfonium compound, S-adenosylmethionine (AdoMet), one of nature's most versatile molecules, is biosynthesized from methionine and ATP by AdoMet synthetase or methionine adenosyltransferase (MAT) in a 2-step reaction in which the energy-rich sulfonium compound is formed by dephosphorylation of ATP. All living cells, with the only exception of some parasites and infectious agents, express MAT.
摘要
天然且广泛存在的锍化合物S-腺苷甲硫氨酸（AdoMet）是自然界中最具多功能性的分子之一，它由蛋氨酸和ATP通过腺苷甲硫氨酸合成酶或蛋氨酸腺苷转移酶（MAT）经两步反应生物合成，在该反应中，通过ATP的去磷酸化形成富含能量的锍化合物。除了一些寄生虫和传染因子外，所有活细胞都表达MAT。
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