腺苷甲硫氨酸合成酶有缺陷的突变体对S-腺苷甲硫氨酸的合成
The synthesis of S-adenosylmethionine by mutants with defects in S-adenosylmethionine synthetase.
作者信息
Hobson A C
出版信息
Mol Gen Genet. 1976 Feb 27;144(1):87-95. doi: 10.1007/BF00277310.
PMID:772417
Abstract
Some metK mutants of Salmonella typhimurium with constitutive methionine biosynthesis have no detectable S-adenosylmethionine (SAM) synthetase, the enzyme which converts methionine to SAM, the postulated corepressor of the methionine pathway. However, these mutants are not auxotrophic for SAM, an essential compound for many reactions.
摘要
一些具有组成型甲硫氨酸生物合成能力的鼠伤寒沙门氏菌metK突变体没有可检测到的S-腺苷甲硫氨酸（SAM）合成酶，该酶可将甲硫氨酸转化为SAM，而SAM被认为是甲硫氨酸途径的核心阻遏物。然而，这些突变体对SAM并不营养缺陷，SAM是许多反应所必需的化合物。
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