Anversa P, Fitzpatrick D, Argani S, Capasso J M
Department of Medicine, New York Medical College, Valhalla 10595.
Circ Res. 1991 Oct;69(4):1159-64. doi: 10.1161/01.res.69.4.1159.
To determine whether myocyte mitotic division occurs in the adult mammalian heart and whether this cellular process is affected by aging, we measured the percentage of myocyte nuclei showing metaphase chromosomes in myocytes isolated from the left and right ventricles of rats at 8-12, 19-24, and 28-32 months after birth. Metaphase chromosomes were found at all ages in both ventricles. However, from 8-12 to 28-32 months, the fraction of nuclei exhibiting metaphase chromosomes increased 6.3-fold and 2.3-fold in the left and right ventricles, respectively. Thus, myocyte cellular hyperplasia is present in the adult and aging myocardium as a compensatory mechanism to regenerate tissue mass and recover function, which are lost with the progression of life and senescence.
为了确定成年哺乳动物心脏中是否发生心肌细胞有丝分裂以及该细胞过程是否受衰老影响，我们测量了出生后8 - 12个月、19 - 24个月和28 - 32个月大鼠左心室和右心室分离出的心肌细胞中显示中期染色体的心肌细胞核百分比。在两个心室的所有年龄段均发现了中期染色体。然而，从8 - 12个月到28 - 32个月，左心室和右心室中显示中期染色体的细胞核比例分别增加了6.3倍和2.3倍。因此，成年和衰老心肌中存在心肌细胞增生，作为一种补偿机制以再生组织质量并恢复随着生命进程和衰老而丧失的功能。
