Chou Yen-Yin, Huang Po-Chin, Lee Ching-Chang, Wu Meng-Hsing, Lin Shio-Jean
Department of Pediatrics, National Cheng Kung University Medical College and Hospital, Tainan, Taiwan.
J Pediatr Endocrinol Metab. 2009 Jan;22(1):69-77. doi: 10.1515/jpem.2009.22.1.69.
The aim of this study was to determine the levels of phthalate ester metabolites in girls in early puberty, and the associated environmental factors for phthalate exposure. A case-control study was conducted in which we recruited girls in early puberty, including 30 girls with premature thelarche (PT) and 26 with central precocious puberty (CPP), and 33 normal controls. The mean urine levels of monomethyl phthalate (MMP) were significantly higher in the PT group (96.5 +/- 134.0 ng/ml) than in the control group (26.4 +/- 30.0 ng/ml; p = 0.005). The levels of monobutyl phthalate (MBuP) correlated with the intake of seafood, drink and the use of plastic cups. The levels of mono-(2-ethylhexyl) phthalate (MEHP) correlated with the intake of seafood and meat and exposure plastic handi-wrap. Significantly higher MMP in the PT girls revealed that phthalate may be one of the environmental causes of early puberty in Taiwanese girls.
本研究的目的是确定青春期早期女孩邻苯二甲酸酯代谢物的水平，以及邻苯二甲酸酯暴露的相关环境因素。我们开展了一项病例对照研究，招募了青春期早期女孩，包括30例乳房过早发育（PT）女孩和26例中枢性性早熟（CPP）女孩，以及33例正常对照。PT组尿中邻苯二甲酸单甲酯（MMP）的平均水平（96.5±134.0 ng/ml）显著高于对照组（26.4±30.0 ng/ml；p = 0.005）。邻苯二甲酸单丁酯（MBuP）的水平与海鲜、饮料摄入量及塑料杯使用情况相关。邻苯二甲酸单（2-乙基己基）酯（MEHP）的水平与海鲜和肉类摄入量及接触塑料保鲜膜情况相关。PT女孩中MMP显著升高表明，邻苯二甲酸酯可能是台湾女孩青春期早熟的环境原因之一。
