Mariano Adrian V, Su Wansheng, Guharay Samar K
The MITRE Corporation, 7515 Colshire Drive, McLean, Virginia 22102, USA.
Anal Chem. 2009 May 1;81(9):3385-91. doi: 10.1021/ac802652f.
The effect of space charge on the performance of an Ion Mobility Spectrometry (IMS) system becomes more important as the system is made smaller. We use the SIMION software package with the Statistical Diffusion Simulation (SDS) module and SIMION's new capability to solve the Poisson equation to study the effect of space charge on ion loss and resolving power in IMS systems. We consider IMS systems ranging in length from 50 mm to 150 mm and in diameter from 8.33 mm to 50 mm with a fixed electric field of 50 V/mm. We also examine a system with a length of 50 mm, a diameter of 16.7 mm, and an electric field of 16.7 V/mm. We assume that any charge density can be injected into the IMS system, and we have obtained expressions that predict the ion loss and resolving power of IMS systems as a function of input charge density and drift tube aspect ratio (length/diameter).
随着离子迁移谱（IMS）系统尺寸的减小，空间电荷对其性能的影响变得更加重要。我们使用带有统计扩散模拟（SDS）模块的SIMION软件包以及SIMION求解泊松方程的新功能，来研究空间电荷对IMS系统中离子损失和分辨率的影响。我们考虑长度在50毫米至150毫米之间、直径在8.33毫米至50毫米之间且固定电场为50 V/mm的IMS系统。我们还研究了一个长度为50毫米、直径为16.7毫米且电场为16.7 V/mm的系统。我们假设可以向IMS系统中注入任何电荷密度，并得到了预测IMS系统离子损失和分辨率与输入电荷密度及漂移管长宽比（长度/直径）关系的表达式。
