Davila-Roman V G, Barzilai B, Wareing T H, Murphy S F, Kouchoukos N T
Cardiovascular Division, Washington University School of Medicine, St. Louis, MO 63110.
Circulation. 1991 Nov;84(5 Suppl):III47-53.
Dislodgement of atheromatous plaque from the ascending aorta following manipulation is one of the principal causes of stroke following cardiac surgery. To define clinical correlates that predict the presence of severe atherosclerosis, we performed ultrasonographic evaluation of the ascending aorta at the time of cardiac surgery in 100 consecutive patients. The ascending aorta was divided into three equal segments for analysis, and the severity of atherosclerosis was determined as mild when intimal thickening (less than 3 mm) was localized to one segment, moderate when intimal thickening (greater than 3 mm) was present in one or two segments, and severe when intimal thickening (greater than 3 mm) was present throughout the entire circumference in all three segments. Thirty-eight percent of the studies were normal, mild atherosclerosis was present in 33%, moderate atherosclerosis in 19%, and severe atherosclerosis in 10% of the patients. Palpation of the ascending aorta to detect atherosclerosis significantly underestimated the presence (p less than 0.001) and severity (p less than 0.001) of atherosclerosis when compared with ultrasonography. Age, carotid artery disease, diabetes, gender, smoking, and hypertension were evaluated for their ability to discriminate between normal and severely atherosclerotic aortas. Stepwise logistic regression analysis showed age (p less than 0.02) and diabetes (p less than 0.04) to be significant independent predictors of the presence of severe atherosclerosis in the ascending aorta. Based on the ultrasonographic findings, the operative procedure was altered to reduce the risk of embolization in 17% of the patients. We conclude that high-resolution images of the ascending aorta for identification of atherosclerosis can be obtained by ultrasonography.(ABSTRACT TRUNCATED AT 250 WORDS)
心脏手术后中风的主要原因之一是操作后动脉粥样硬化斑块从升主动脉脱落。为了确定预测严重动脉粥样硬化存在的临床相关因素,我们对100例连续心脏手术患者在手术时进行了升主动脉超声评估。将升主动脉分为三个相等的节段进行分析,当内膜增厚(小于3mm)局限于一个节段时,动脉粥样硬化严重程度判定为轻度;当一个或两个节段出现内膜增厚(大于3mm)时,判定为中度;当所有三个节段整个圆周均出现内膜增厚(大于3mm)时,判定为重度。38%的检查结果正常,33%的患者存在轻度动脉粥样硬化,19%为中度,10%为重度。与超声检查相比,触诊升主动脉以检测动脉粥样硬化显著低估了其存在(p<0.001)和严重程度(p<0.001)。评估了年龄、颈动脉疾病、糖尿病、性别、吸烟和高血压区分正常与严重动脉粥样硬化主动脉的能力。逐步逻辑回归分析显示年龄(p<0.02)和糖尿病(p<0.04)是升主动脉严重动脉粥样硬化存在的显著独立预测因素。根据超声检查结果,17%的患者改变了手术操作以降低栓塞风险。我们得出结论,通过超声检查可获得用于识别动脉粥样硬化的升主动脉高分辨率图像。(摘要截短至250字)