Vale Paulo, Veloso Vera, Amorim Ana
Instituto Nacional dos Recursos Biológicos - IPIMAR (INRB-IPIMAR), Av. Brasília, s/n, 1449-006 Lisboa, Portugal.
Toxicon. 2009 Aug;54(2):145-52. doi: 10.1016/j.toxicon.2009.03.026. Epub 2009 Apr 2.
Microalgae of the genus Dinophysis and Prorocentrum are known producers of okadaites, responsible for the human syndrome known as diarrhetic shellfish poisoning (DSP). In temperate regions, only species from the genus Dinophysis are commonly held responsible for shellfish contamination. This is probably related to the different ecological strategies of the two genera, namely the planktonic nature of Dinophysis versus the benthic/epiphytic nature of toxic Prorocentrum species. In recent years, the threat of global warming has drawn attention to the study of benthic toxic microalgae in southern European waters. Here we present results on the toxin production and toxin profile of a Prorocentrum lima strain isolated from the Portuguese coast. This strain, IO66-01, presented a mean growth rate of 0.49 divisions d(-1), not common in temperate strains, and only comparable with tropical strains. The parent toxins found were okadaic acid (OA) and dinophysistoxin-1 (DTX1). The major diol esters were D8- and D9- congeners of both OA and DTX1.
裸甲藻属和原甲藻属的微藻是已知的冈田酸类毒素产生者，会引发被称为腹泻性贝类中毒（DSP）的人类综合征。在温带地区，通常只有裸甲藻属的物种被认为应对贝类污染负责。这可能与这两个属不同的生态策略有关，即裸甲藻的浮游性质与有毒原甲藻物种的底栖/附生性质。近年来，全球变暖的威胁促使人们关注对南欧海域底栖有毒微藻的研究。在此，我们展示了从葡萄牙海岸分离出的利马原甲藻菌株的毒素产生情况和毒素谱。该菌株IO66 - 01的平均生长速率为0.49次分裂/天（d(-1)），这在温带菌株中并不常见，仅与热带菌株相当。检测到的母体毒素为冈田酸（OA）和鳍藻毒素 - 1（DTX1）。主要的二醇酯是OA和DTX1的D8 - 和D9 - 同系物。
