Jamshidi Mahin, Jahromi Abdolreza Sotoodeh, Davoodian Parivash, Amirian Malihe, Zangeneh Mehrangiz, Jadcareh Fatemeh
Infectious and Tropical Diseases Research Center, Hormozgan University of Medical Sciences, Banddar Abbas, Iran.
Taiwan J Obstet Gynecol. 2009 Mar;48(1):46-8. doi: 10.1016/S1028-4559(09)60034-6.
There are many studies supporting the role of certain asymptomatic infections such as Listeria monocytogenes (L. monocytogenes) in spontaneous abortion. In some cases, latent listeriosis may complicate the pregnancy, and serologic tests can, therefore, be used to detect the disease. This study was designed to assess the relationship between seropositivity for L. monocytogenes and spontaneous abortion.
A total of 250 women with previous spontaneous abortion and a control group of 200 women with normal full-term deliveries entered the study as case and control groups, respectively. Demographic characteristics were recorded for each subject, and serum samples were obtained from all participants. All serum samples were examined using the indirect immunofluorescence antibody test for L. monocytogenes antibody. Data was analyzed using Chi-squared and t tests.
The average age of participants was 25.6 +/- 7.6 years in cases and 25.3 +/- 6.5 years in controls. Eighty-nine (35.6%) of the cases with abortion and 35 (17.5%) of the control group were positive for L. monocytogenes antibody (p = 0.001). No relationship was observed between the number of pregnancies and infection with L. monocytogenes (p = 0.4), or between the number of previous abortions and L. monocytogenes seropositivity (p = 0.2).
We suggest monitoring L. monocytogenes seroprevalence in pregnant women at high risk of threatened abortion, and further microbiological assessment of symptomatic women for detection of L. monocytogenes and insidious infection.
有许多研究支持某些无症状感染，如单核细胞增生李斯特菌（L. monocytogenes）在自然流产中的作用。在某些情况下，潜伏性李斯特菌病可能使妊娠复杂化，因此血清学检测可用于检测该疾病。本研究旨在评估单核细胞增生李斯特菌血清阳性与自然流产之间的关系。
共有250名有自然流产史的女性和200名正常足月分娩的女性作为病例组和对照组分别进入研究。记录每个受试者的人口统计学特征，并从所有参与者中获取血清样本。所有血清样本均采用间接免疫荧光抗体试验检测单核细胞增生李斯特菌抗体。数据采用卡方检验和t检验进行分析。
病例组参与者的平均年龄为25.6±7.6岁，对照组为25.3±6.5岁。89例（35.6%）流产病例和35例（17.5%）对照组单核细胞增生李斯特菌抗体呈阳性（p = 0.001）。未观察到妊娠次数与单核细胞增生李斯特菌感染之间的关系（p = 0.4），也未观察到既往流产次数与单核细胞增生李斯特菌血清阳性之间的关系（p = 0.2）。
我们建议对有流产风险的高危孕妇监测单核细胞增生李斯特菌血清流行率，并对有症状的女性进行进一步的微生物学评估，以检测单核细胞增生李斯特菌和隐匿性感染。
