Yuan Tingting, Hu Yunjian, Pian Yaya
Department of Laboratory Medicine, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, PR China.
Clinical Laboratory Medicine, Peking University Ninth School of Clinical Medicine, Beijing, China.
Heliyon. 2023 Mar 31;9(4):e14980. doi: 10.1016/j.heliyon.2023.e14980. eCollection 2023 Apr.
Pregnant women are at a high risk of contracting listeriosis; however, there have been only a few clinical reports of maternal bacteremia occurring before 20 weeks of gestation in China. In this case report, a 28-year-old pregnant woman at 16 weeks and 4 days of gestation was admitted to our hospital suffering from fever for four days. The patient was initially diagnosed with an upper respiratory tract infection at the local community hospital; nevertheless, the cause of the infection was unknown. In our hospital, she was diagnosed with () infection by the blood culture system. Before the results of blood culture were obtained, ceftriaxone and cefazolin were given for three days respectively based on clinical experience. However, the fever didn't reduce until she was treated with ampicillin. This pathogen was further identified as ST87 by serotyping, multilocus sequence typing (MLST), and virulence gene amplification. Finally, a healthy baby boy was born in our hospital, and the neonate was developing well at the 6-week postnatal follow-up visit. This case report suggests that patients with ST87-caused maternal listeriosis can have a good prognosis; however, more clinical information and molecular experiments are needed to confirm our hypothesis.
孕妇感染李斯特菌病的风险很高;然而,在中国,关于妊娠20周前发生母体菌血症的临床报告仅有少数几例。在本病例报告中,一名妊娠16周零4天的28岁孕妇因发热4天入住我院。该患者最初在当地社区医院被诊断为上呼吸道感染;然而,感染原因不明。在我院,通过血培养系统诊断为()感染。在获得血培养结果之前,根据临床经验分别给予头孢曲松和头孢唑林治疗3天。然而,直到使用氨苄西林治疗后发热才消退。通过血清分型、多位点序列分型(MLST)和毒力基因扩增,该病原体进一步被鉴定为ST87。最后,我院一名健康男婴出生,新生儿在出生后6周的随访中发育良好。本病例报告表明,由ST87引起的母体李斯特菌病患者预后良好;然而,需要更多的临床信息和分子实验来证实我们的假设。