Awofisayo A, Amar C, Ruggles R, Elson R, Adak G K, Mook P, Grant K A
Centre for Infectious Disease Surveillance and Control, Public Health England,UK.
Gastrointestinal Bacteria Reference Unit, Public Health England,UK.
Epidemiol Infect. 2015 Jan;143(2):249-56. doi: 10.1017/S0950268814000594. Epub 2014 Mar 20.
Listeriosis is a rare but severe foodborne disease with low morbidity and high case-fatality rates. Pregnant women, unborn and newborn babies are among the high-risk groups for listeriosis. We examined listeriosis cases reported to the enhanced surveillance system in England and Wales from 1990 to 2010 to identify risk factors influencing outcome. Cases were defined as pregnancy-associated if Listeria monocytogenes was isolated from a pregnant woman or newborn infants aged <28 days. Of the 3088 cases reported, pregnancy-associated listeriosis accounted for 462 (15%) cases and 315 cases resulted in a live birth. Several factors were identified as affecting the severity and outcome of listeriosis in pregnancy in both mother and child including: presence or absence of maternal symptoms, gestational age at onset of symptoms, and clinical presentation in the infant (meningitis or septicaemia). Deprivation, ethnicity and molecular serotype had no effect on outcome.
李斯特菌病是一种罕见但严重的食源性疾病，发病率低但病死率高。孕妇、未出生及新生儿是患李斯特菌病的高危人群。我们调查了1990年至2010年向英格兰和威尔士强化监测系统报告的李斯特菌病病例，以确定影响预后的危险因素。如果从孕妇或年龄小于28天的新生儿中分离出单核细胞增生李斯特菌，则病例被定义为与妊娠相关。在报告的3088例病例中，与妊娠相关的李斯特菌病占462例（15%），315例分娩活婴。已确定有几个因素会影响妊娠期间李斯特菌病母婴的严重程度和预后，包括：母亲是否有症状、症状出现时的孕周以及婴儿的临床表现（脑膜炎或败血症）。贫困、种族和分子血清型对预后没有影响。
