Suenaga R, Evans M, Abdou N I
Innunology Research Laboratory, St. Luke's Hospital, Kansas City, Missouri 64111.
Clin Immunol Immunopathol. 1991 Dec;61(3):320-31. doi: 10.1016/s0090-1229(05)80004-2.
IgG anti-DNA antibodies of a lupus patient during active and inactive stages of her disease were studied. There were no significant differences in the amounts, in double-stranded DNA-binding activity, or in complement-fixing ability between purified IgG anti-DNA antibodies of both stages. However, their idiotype (Id) expressions were different as revealed by binding to rabbit anti-Ids raised against each of the anti-DNA antibodies. Moreover, the active stage anti-DNA antibodies had higher activity and less cross-reactivity with polynucleotides. Dominant anti-DNA populations during the active and inactive stages of systemic lupus erythematosus are clonally and qualitatively different.
对一位狼疮患者疾病活动期和非活动期的IgG抗DNA抗体进行了研究。两个阶段纯化的IgG抗DNA抗体在数量、双链DNA结合活性或补体固定能力方面均无显著差异。然而，通过与针对每种抗DNA抗体产生的兔抗独特型（Id）结合发现，它们的独特型（Id）表达不同。此外，活动期抗DNA抗体具有更高的活性，与多核苷酸的交叉反应性更低。系统性红斑狼疮活动期和非活动期的主要抗DNA群体在克隆和质量上存在差异。
