Gyan Ben, Goka Bamenla Quarm, Adjei George O, Tetteh John K A, Kusi Kwadwo Asamoah, Aikins Anastasia, Dodoo Daniel, Lesser Martin L, Sison Cristina P, Das Sanchita, Howard Marion E, Milbank Elizabeth, Fischer Kimberly, Rafii Shahin, Jin David, Golightly Linnie M
Department of Immunology, Noguchi Memorial Institute for Medical Research, Legon, Ghana.
Am J Trop Med Hyg. 2009 Apr;80(4):541-6.
Damage to the cerebral microvasculature is a feature of cerebral malaria. Circulating endothelial progenitor cells are needed for microvascular repair. Based on this knowledge, we hypothesized that the failure to mobilize sufficient circulating endothelial progenitor cells to the cerebral microvasculature is a pathophysiologic feature of cerebral malaria. To test this hypothesis, we compared peripheral blood levels of CD34 (+)/VEGFR2(+) and CD34 (+)/CD133(+) cells and plasma levels of the chemokine stromal cell-derived growth factor 1 (SDF-1) in 214 children in Accra, Ghana. Children with cerebral malaria had lower levels of CD34 (+)/VEGFR2(+) and CD34 (+)/CD133(+) cells compared with those with uncomplicated malaria, asymptomatic parasitemia, or healthy controls. SDF-1 levels were higher in children with acute malaria compared with healthy controls. Together, these results uncover a potentially novel role for endothelial progenitor cell mobilization in the pathophysiology of cerebral malaria.
脑微血管损伤是脑型疟疾的一个特征。微血管修复需要循环内皮祖细胞。基于这一认识，我们推测未能动员足够的循环内皮祖细胞至脑微血管是脑型疟疾的一个病理生理特征。为验证这一假设，我们比较了加纳阿克拉214名儿童外周血中CD34(+)/VEGFR2(+)和CD34(+)/CD133(+)细胞水平以及趋化因子基质细胞衍生生长因子1(SDF-1)的血浆水平。与患非重症疟疾、无症状寄生虫血症的儿童或健康对照相比，患脑型疟疾的儿童CD34(+)/VEGFR2(+)和CD34(+)/CD133(+)细胞水平较低。与健康对照相比，急性疟疾儿童的SDF-1水平较高。这些结果共同揭示了内皮祖细胞动员在脑型疟疾病理生理学中一个潜在的新作用。
