Schmidt Markus, Dogan Canan, Birdir Cahit, Kuhn Ulrich, Gellhaus Alexandra, Kimmig Rainer, Kasimir-Bauer Sabine
Department of Gynecology and Obstetrics, University of Duisburg-Essen, Essen, Germany.
Gynakol Geburtshilfliche Rundsch. 2009;49(2):94-9. doi: 10.1159/000197908. Epub 2009 Mar 25.
An imbalance between angiogenic and antiangiogenic factors plays a fundamental role in the pathogenesis of preeclampsia. Serum levels of placental growth factor (PLGF), a factor promoting angiogenesis, in patients with preeclampsia are significantly lower than in nonpreeclamptic pregnancies. This study was designed to answer the question whether the measurement of PLGF at the beginning of the second trimester might be a predictive factor for the appearance of preeclampsia.
Serum samples of 61 women were collected between 15 and 18 weeks of pregnancy. PLGF levels were measured using a human PLGF ELISA and correlated with the outcomes of pregnancy.
7 women (11.47%) developed preeclampsia during pregnancy. Their PLGF levels between 15 and 18 weeks of pregnancy were significantly lower (p < 0.001) compared to the nonpreeclamptic pregnancies. Using a PLGF level of 41.84 pg/ml as a cutoff, this test has a sensitivity of 0.87 and a specificity of 0.83.
Women who will develop preeclampsia in the course of pregnancy already have a significantly lower expression of PLGF between 15 and 18 weeks of pregnancy compared to those who will not. This test offers new possibilities in the prediction of preeclampsia.
血管生成因子与抗血管生成因子之间的失衡在子痫前期的发病机制中起关键作用。子痫前期患者血清中促进血管生成的胎盘生长因子（PLGF）水平显著低于非子痫前期妊娠患者。本研究旨在回答孕中期开始时检测PLGF是否可能是子痫前期发生的预测因素这一问题。
收集61名孕妇在妊娠15至18周之间的血清样本。使用人PLGF酶联免疫吸附测定法检测PLGF水平，并将其与妊娠结局相关联。
7名女性（11.47%）在孕期发生子痫前期。与未发生子痫前期的妊娠相比，她们在妊娠15至18周时的PLGF水平显著降低（p < 0.001）。以41.84 pg/ml的PLGF水平作为临界值，该检测的灵敏度为0.87，特异性为0.83。
与未发生子痫前期的孕妇相比，孕期将发生子痫前期的女性在妊娠15至18周时PLGF表达已显著降低。该检测为子痫前期的预测提供了新的可能性。
