Bolosiu H D, Rus V, Parasca I, Dutu A, Malide D
Department of Rheumatology, Medical Clinic No. 2, Cluj-Napoca, Romania.
Clin Exp Rheumatol. 1991 Jul-Aug;9(4):395-8.
Von Willebrand factor (vWf), an endothelial product that arises in plasma in conditions associated with vascular damage and acute phase reaction, was evaluated in paired samples of plasma and synovial fluid obtained from 54 patients with inflammatory joint effusion, 19 patients with osteoarthritis, and from the plasma of 19 controls. Synovial fluid levels of vWf were detected in 36 of the patients. The mean value of vWf in the inflammatory joint effusion group was 18.27 +/- 3.03%, significantly higher than the mean value of 7.7 +/- 4.4% found in the osteoarthritis group (p less than 0.01). The significant difference between these groups was maintained when vWf was expressed as a ratio of albumin. vWf was correlated with synovial fluid levels of alpha-1-antitrypsin (r = 0.83, p less than 0.01) and with the white cell count (r = 0.74, p less than 0.01), but not with the levels of immunoglobulins or C3. vWf in the synovial fluid may reflect the local degree of inflammation.
血管性血友病因子（vWf）是一种内皮细胞产物，在与血管损伤和急性期反应相关的情况下出现在血浆中。我们对54例炎性关节积液患者、19例骨关节炎患者的配对血浆和滑液样本以及19例对照者的血浆进行了评估。在36例患者中检测到了滑液中的vWf水平。炎性关节积液组vWf的平均值为18.27 +/- 3.03%，显著高于骨关节炎组中发现的7.7 +/- 4.4%的平均值（p < 0.01）。当vWf以白蛋白比率表示时，这些组之间的显著差异仍然存在。vWf与α-1-抗胰蛋白酶的滑液水平相关（r = 0.83，p < 0.01），与白细胞计数相关（r = 0.74，p < 0.01），但与免疫球蛋白或C3的水平无关。滑液中的vWf可能反映了局部炎症程度。
