Chan Yvonne, Kuhn Frederick A
Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, Ontario, Canada.
Curr Opin Otolaryngol Head Neck Surg. 2009 Jun;17(3):204-8. doi: 10.1097/MOO.0b013e32832ac393.
This review is timely and relevant because rhinosinusitis is a disease process that is heterogeneous in its clinical and pathologic manifestations. Therefore, no one causative factor has been identified that fully accounts for all rhinosinusitis. The purpose of this review is to provide a succinct update of rhinosinusitis classification, pathophysiology, and management given the new movement toward evidence-based guidelines.
The term rhinosinusitis reflects the concurrent inflammatory and infectious processes that affect the nasal passages and the contiguous paranasal sinuses. The most recent classification scheme is intended primarily to guide clinical research and divides rhinosinusitis into four categories: acute bacterial rhinosinusitis, chronic sinusitis with nasal polyposis, chronic rhinosinusitis with nasal polyposis, and allergic fungal rhinosinusitis. The goals of treatment include reduction of mucosal edema, reestablishment of sinus ventilation, and eradication of infecting pathogens. Multiple therapies are available for the management of chronic rhinosinusitis, including antibiotics, hypertonic and isotonic saline irrigations or sprays, topical and systemic glucocorticords, antileukotriene agents, and endoscopic sinus surgery.
Rhinosinusitis is a common medical problem that interferes with patient quality of life and loss of work productivity. Because of the heterogeneity that underlies its pathology, no one treatment regimen exists for the management of rhinosinusitis.
本综述既及时又具相关性,因为鼻窦炎是一种临床和病理表现均具有异质性的疾病过程。因此,尚未确定一个能完全解释所有鼻窦炎的致病因素。本综述的目的是鉴于循证指南的新动向,对鼻窦炎的分类、病理生理学及治疗作简要更新。
鼻窦炎一词反映了影响鼻腔通道及相邻鼻窦的并发炎症和感染过程。最新分类方案主要旨在指导临床研究,将鼻窦炎分为四类:急性细菌性鼻窦炎、伴鼻息肉的慢性鼻窦炎、不伴鼻息肉的慢性鼻窦炎及变应性真菌性鼻窦炎。治疗目标包括减轻黏膜水肿、恢复鼻窦通气及根除感染病原体。慢性鼻窦炎的治疗有多种方法,包括使用抗生素、高渗和等渗盐水冲洗或喷雾、局部和全身用糖皮质激素、抗白三烯药物以及鼻内镜鼻窦手术。
鼻窦炎是一个常见的医学问题,会影响患者的生活质量并导致工作效率下降。由于其病理存在异质性,目前尚无一种治疗方案可用于鼻窦炎的治疗。