Jordan B, Eger K, Zierz S
Klinik und Poliklinik für Neurologie, Martin-Luther-Universität Halle-Wittenberg, Ernst-Grube-Strasse 40, 06097, Halle/Saale, Deutschland.
Nervenarzt. 2009 Jun;80(6):708-11. doi: 10.1007/s00115-009-2689-1.
Neuromuscular diseases accompanying thymoma include myasthenia gravis, polymyositis, dermatomyositis, and neuromyotonia. Usually 50% of patients with thymoma develop myasthenia gravis. However, only 5% show polymyositis as an accompanying paraneoplastic phenomenon. We report the case of a patient with thymoma showing myasthenia gravis as well as polymyositis. Due to the simultaneous occurrence of these paraneoplastic diseases, the criteria for exact diagnosis (serum creatine kinase, EMG, ocular involvement) overlap. This diagnostic dilemma can appreciably complicate the therapeutic approach.
伴发胸腺瘤的神经肌肉疾病包括重症肌无力、多发性肌炎、皮肌炎和神经性肌强直。通常，50%的胸腺瘤患者会发生重症肌无力。然而，只有5%的患者表现为多发性肌炎这一伴随的副肿瘤现象。我们报告了1例同时患有重症肌无力和多发性肌炎的胸腺瘤患者。由于这些副肿瘤性疾病同时出现，准确诊断的标准（血清肌酸激酶、肌电图、眼部受累情况）相互重叠。这种诊断困境会显著使治疗方法复杂化。
