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袖状胃切除术后有症状的胆囊结石。

Symptomatic gallstones after sleeve gastrectomy.

机构信息

The Bariatric and Metabolic Institute, Section of Minimally Invasive and Endoscopic Surgery, 2950 Cleveland Clinic Boulevard, Weston, FL 33331, USA.

出版信息

Surg Endosc. 2009 Nov;23(11):2488-92. doi: 10.1007/s00464-009-0422-6. Epub 2009 Apr 4.

Abstract

BACKGROUND

Cholelithiasis is a common complication after bariatric surgery. Pure restrictive procedures such as sleeve gastrectomy and gastric banding theoretically should result in less gallstone formation because the food continues to follow the normal gastrointestinal transit, maintaining the enteric-endocrine reflex intact. To the authors' knowledge, the literature has no studies that analyze the incidence of gallstone formation after sleeve gastrectomy. This study aimed to compare the rates of symptomatic gallstones between laparoscopic Roux-en-Y gastric bypass (RYGBP) and sleeve gastrectomy (SG).

METHODS

A retrospective chart review of patients who underwent laparoscopic RYGBP and SG between 2004 and 2006 was performed. The patients with previous cholecystectomy, known gallstones with or without concomitant cholecystectomy, and previous weight-reduction operations were excluded from the analysis. The outcome measures were the numbers of patients who had experienced symptomatic and complicated gallstones. Using Cox regression analysis, comparisons was made between the patients with laparoscopic RYGBP (group A) and those with laparoscopic SG (group B).

RESULTS

Groups A excluded 174 (26%) of 670 patients, and group B excluded 27 (34.2%) of 79 patients. The patients in group A had a significantly higher preoperative body mass index (BMI) than those in group B. Additionally, more group A than group B patients had a BMI exceeding 45 and more than a 25% loss of original weight. No significant difference in the development of symptomatic (8.7% vs. 3.8%; p = 0.296) or complicated (1.8% vs. 1.9%; p = 0.956) gallstones was noted between the two groups

CONCLUSIONS

There was no significant difference in symptomatic or complicated gallstone disease between the patients treated with laparoscopic SG and those treated with laparoscopic RYGBP. Routine prophylactic cholecystectomy should not be recommended for weight reduction during laparoscopic SG.

摘要

背景

胆石症是减重手术后的常见并发症。袖状胃切除术和胃带术等单纯限制型手术理论上应减少胆结石形成,因为食物继续遵循正常的胃肠道转运,使肠内分泌反射保持完整。据作者所知,文献中尚无分析袖状胃切除术后胆结石形成发生率的研究。本研究旨在比较腹腔镜胃旁路术(RYGBP)和袖状胃切除术(SG)后症状性胆结石的发生率。

方法

对 2004 年至 2006 年间接受腹腔镜 RYGBP 和 SG 的患者进行回顾性图表审查。排除了既往有胆囊切除术、已知有或无胆囊切除术的胆结石以及既往减重手术的患者。主要观察指标为出现症状性和复杂胆结石的患者数量。使用 Cox 回归分析比较接受腹腔镜 RYGBP(A 组)和腹腔镜 SG(B 组)治疗的患者。

结果

A 组排除了 670 例患者中的 174 例(26%),B 组排除了 79 例患者中的 27 例(34.2%)。A 组患者的术前体重指数(BMI)明显高于 B 组。此外,A 组患者的 BMI 超过 45 和体重减轻超过 25%的比例明显高于 B 组。两组患者症状性(8.7%比 3.8%;p=0.296)或复杂性(1.8%比 1.9%;p=0.956)胆结石的发展无显著差异。

结论

腹腔镜 SG 与腹腔镜 RYGBP 治疗的患者之间在症状性或复杂性胆囊疾病方面无显著差异。对于腹腔镜 SG 期间的减重,不建议常规预防性胆囊切除术。

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