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[肥胖:骨关节炎的危险因素及预测指标]

[Obesity: risk factor and predictor of osteoarthritis].

作者信息

Grazio Simeon, Balen Diana

机构信息

Klinika za reumatologiju, fizikalnu medicinu i rehabilitaciju, Klinicka bolnica Sestre milosrdnice, Zagreb.

出版信息

Lijec Vjesn. 2009 Jan-Feb;131(1-2):22-6.

Abstract

Osteoarthritis (OA) is the most common articular disease of the developed world and a leading cause of chronic disability, mostly as a consequence of the knee OA and/or hip OA. In spite of misrecognition of the exact cause, a number of studies have shown that obesity represents one of the most important risk factors and it is also a predictor for progression of OA, especially of a knee joint and less of the hip joint. Relationship between body mass index (BMI) and OA of the knee is mainly linear, and duration of increasedjoint loading or gaining weight is also significant. Studies about obesity and hand OA are contradictory. Risk gradient for BMI and the hip OA is somewhere between the knee and the hand gradient. Disability may be significantly relieved if a body weight is decreased for more than 5.1%. Twenty seven percent of cases of hip arthroplasty and 69% knee arthroplasty may be attributed to obesity. Nonpharmacologic treatment of OA includes treatment of obesity.

摘要

骨关节炎(OA)是发达国家最常见的关节疾病,也是导致慢性残疾的主要原因,主要是膝骨关节炎和/或髋骨关节炎所致。尽管确切病因尚未明确,但多项研究表明,肥胖是最重要的危险因素之一,也是骨关节炎进展的预测指标,尤其是膝关节骨关节炎,髋关节骨关节炎的情况相对较少。体重指数(BMI)与膝骨关节炎之间的关系主要呈线性,关节负荷增加或体重增加的持续时间也很重要。关于肥胖与手部骨关节炎的研究结果相互矛盾。BMI与髋骨关节炎的风险梯度介于膝关节和手部梯度之间。如果体重降低超过5.1%,残疾情况可能会显著缓解。27%的髋关节置换病例和69%的膝关节置换病例可能归因于肥胖。骨关节炎的非药物治疗包括肥胖治疗。

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