Abe Masatoshi, Syuto Tomoko, Hasegawa Michiko, Yokoyama Yoko, Ishikawa Osamu
Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Japan.
J Dermatol. 2009 Apr;36(4):197-201. doi: 10.1111/j.1346-8138.2009.00623.x.
In this study, we aimed at confirming the clinical usefulness of a supplementary additional cyclosporin microemulsion preconcentrate (CyA MEPC) administration in 15 patients with psoriasis vulgaris whose disease activity had been unchanged or exacerbated with topical maxacalcitol treatment. Each patient took a supplementary CyA MEPC administration, 2.5 mg/kg per day in addition to maxacalcitol ointment therapy. When the Psoriasis Area and Severity Index (PASI) score revealed over a 75% decrease against the initial value, the administration of CyA MEPC was tapered off, and a topical application of maxacalcitol ointment was continued for the maintenance phase. All patients could obtain improvement within 12 weeks. In 12 patients whose PASI score reduced over 75%, CyA MEPC was tapered off. Of those, five patients remained in remission by maxacalcitol ointment for over 12 months and three patients for 6 months. In conclusion, this preliminary study may suggest that supplementary therapy of short-term CyA MEPC administration in combination with topical vitamin D3 treatment may be worth trying for patients with moderate psoriasis vulgaris.
在本研究中，我们旨在确认补充额外的环孢素微乳预浓缩剂（CyA MEPC）对15例寻常型银屑病患者的临床效用，这些患者在接受外用马沙骨化醇治疗后疾病活动未改善或加重。每位患者在接受马沙骨化醇软膏治疗的基础上，额外补充CyA MEPC，每日2.5 mg/kg。当银屑病面积和严重程度指数（PASI）评分相对于初始值下降超过75%时，逐渐减少CyA MEPC的给药量，并在维持阶段继续外用马沙骨化醇软膏。所有患者在12周内均有改善。在PASI评分下降超过75%的12例患者中，逐渐减少了CyA MEPC的给药量。其中，5例患者使用马沙骨化醇软膏缓解超过12个月，3例患者缓解6个月。总之，这项初步研究可能表明，对于中度寻常型银屑病患者，短期补充CyA MEPC联合外用维生素D3治疗可能值得一试。
