铱催化的甲基酮与2-(2-氨基苯基)苯并咪唑的氧化交叉偶联反应：便捷合成苯并咪唑并[1,2-]喹唑啉
I-Catalyzed Oxidative Cross-Coupling Reaction of Methyl Ketones and 2-(2-Aminophenyl) Benzimidazole: Facile Access to Benzimidazo[1,2-]quinazoline.
作者信息
Ambethkar Sethurajan, Kalaiselvi Mariappan, Ramamoorthy Jaganathan, Padmini Vediappen
机构信息
Department of Organic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai 625021, Tamil Nadu, India.
出版信息
ACS Omega. 2018 May 8;3(5):5021-5028. doi: 10.1021/acsomega.8b00067. eCollection 2018 May 31.
Abstract
A general and efficient iodine-catalyzed metal-free oxidative cross-coupling reaction of methyl ketones with 2-(1-benzo[]imidazol-2-yl)aniline has been established. This is a new synthetic strategy for the synthesis of benzimidazo[1,2-]quinazoline derivatives involving C(sp)-H oxidation, condensation, and cyclization processes.
摘要
已建立了一种通用且高效的碘催化甲基酮与2-(1-苯并咪唑-2-基)苯胺的无金属氧化交叉偶联反应。这是一种用于合成苯并咪唑并[1,2-]喹唑啉衍生物的新合成策略，涉及C(sp)-H氧化、缩合和环化过程。
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