Wang Wei, Zhao Siwei, Pan Tingrui
Department of Biomedical Engineering, University of California, Davis, USA.
Lab Chip. 2009 Apr 21;9(8):1133-7. doi: 10.1039/b816287e. Epub 2009 Jan 21.
With the major advances in soft lithography and polymer materials, use of microfluidic devices has attracted tremendous attention recently. A simple and fast micromachining process is highly in demand to prototype such a device efficiently and economically. In this paper, we first reported an out-of-cleanroom printing-based integrated microfabrication process, referred to as the lab-on-a-print (LOP), for rapid-prototyping three-dimensional microfluidics. Using this lab-on-a-print process, we demonstrated the potential to accomplish an entire design-to-fabrication cycle within an hour, including about 70 microm resolution of direct-lithography patterning, well-controlled polyimide wet etching, three-dimensional pattern alignment and multilayer wax thermal-fusion packaging. A microfluidic gradient generator was prepared and tested for validation of the lab-on-a-print microfabrication process.
随着软光刻和聚合物材料的重大进展，微流控设备的应用近来备受关注。人们迫切需要一种简单快速的微加工工艺，以便高效且经济地制作此类设备的原型。在本文中，我们首次报道了一种基于洁净室外打印的集成微制造工艺，即“打印式实验室”（LOP），用于快速制作三维微流控器件。利用这种“打印式实验室”工艺，我们展示了在一小时内完成从设计到制造整个周期的潜力，包括约70微米分辨率的直接光刻图案化、可控的聚酰亚胺湿法蚀刻、三维图案对准以及多层蜡热熔封装。制备并测试了一个微流控梯度发生器，以验证“打印式实验室”微制造工艺。
