Al-Otaibi Sultan R, Zadeh Valid Bagher, Al-Abdulrazzaq Adel H, Tarrab Sahar M, Al-Owaidi Hesham A, Mahrous Rahma, Kadyan Randhir S, Najem Nabeel M
Department of Dermatology, Adan Hospital, P.O. Box 2193, Qurain 47372, Kuwait.
Acta Dermatovenerol Alp Pannonica Adriat. 2009 Mar;18(1):13-9.
Current vitiligo therapies require many months of treatment and often result in disappointing outcomes. Treatment with a 308-nm excimer laser has shown promising results in patients with vitiligo.
This controlled prospective trial studied the effectiveness of the 308-nm excimer laser for treating vitiligo in Asians.
Thirty-four patients (14 males and 20 females) with localized vitiligo were enrolled in the study. Vitiligo patches were treated using a 308-nm excimer laser. Lesions were treated twice weekly for 13 weeks. The treatment was started with 50 to 100 mJ/cm2 (according to site) and increased by 50 mJ/cm2 in every session until erythema appeared. Patients were treated for 25 sessions, or until 100% repigmentation, whichever was achieved first. The overall response rate was assessed clinically and by comparison of photographs before and after treatment by two independent investigators.
Twenty-nine patients (12 males and 17 females) completed the study. Lesions on the face responded better than elsewhere on the body. The least responsive areas were the hands and feet. The average number of treatment sessions prior to repigmentation was 11. Untreated control patches remained unchanged. In higher skin phototypes the response was more favorable. There was no significant correlation between the age of the patients and their response to treatment.
The use of the 308-nm excimer laser for the treatment of vitiligo is effective, relatively safe, and more convenient compared to other available modalities of treatment for stable vitiligo with small patches. However, similar to other modalities of treatment, the therapeutic effect is mainly dependent on the location of vitiligo lesions.
目前的白癜风治疗方法需要数月的治疗时间，且常常导致令人失望的结果。308纳米准分子激光治疗白癜风已在患者中显示出有前景的结果。
这项对照前瞻性试验研究了308纳米准分子激光治疗亚洲人白癜风的有效性。
34例局限性白癜风患者（14例男性和20例女性）纳入研究。白癜风斑块采用308纳米准分子激光治疗。皮损每周治疗两次，共13周。治疗起始剂量为50至100 mJ/cm²（根据部位），每次治疗增加50 mJ/cm²，直至出现红斑。患者接受25次治疗，或直至色素完全恢复，以先达到者为准。由两名独立研究者通过临床评估及治疗前后照片对比来评估总体有效率。
29例患者（12例男性和17例女性）完成了研究。面部皮损的反应优于身体其他部位。反应最差的部位是手和脚。色素恢复前的平均治疗次数为11次。未治疗的对照斑块无变化。皮肤光型较高者反应更佳。患者年龄与其对治疗的反应之间无显著相关性。
对于稳定期小面积白癜风，与其他现有治疗方式相比，使用308纳米准分子激光治疗白癜风有效、相对安全且更方便。然而，与其他治疗方式类似，治疗效果主要取决于白癜风皮损的部位。
