Rivera Richard, Antognini Joseph F
Department of Anesthesiology and Pain Medicine, University of California, Davis, CA 95616, USA.
Anesthesiology. 2009 May;110(5):1176-81. doi: 10.1097/ALN.0b013e3181a10207.
Advances in modern medicine and public health have resulted in increased longevity, which in turn has resulted in more elderly patients (arbitrarily defined as aged 65 yr or older) coming to the operating room for a variety of surgical procedures. Even in the absence of comorbidities, these patients, as compared with their younger cohorts, respond differently to various perioperative physiologic trespasses and pharmacologic interventions. In this clinical commentary, we focus on the altered pharmacologic responses elderly patients have during the perioperative period. In many instances, elderly patients are more sensitive to drugs, and for the purposes of this clinical commentary, we use the word sensitivity in its general clinical meaning, i.e., an enhanced response for a given dose of drug that might have a pharmacokinetic or pharmacodynamic explanation.
现代医学和公共卫生的进步使人们的寿命延长，这反过来又导致更多老年患者（年龄界定为65岁及以上）因各种外科手术而进入手术室。即使没有合并症，与年轻患者相比，这些老年患者对各种围手术期生理侵害和药物干预的反应也有所不同。在这篇临床评论中，我们重点关注老年患者在围手术期的药物反应变化。在许多情况下，老年患者对药物更为敏感，在这篇临床评论中，我们使用“敏感”一词的一般临床含义，即对于给定剂量的药物有增强的反应，这可能有药代动力学或药效学方面的解释。
