Institute of Health Promotion and Family Care, University of Pécs, Hungary.
Eur J Gastroenterol Hepatol. 2009 Jul;21(7):739-43. doi: 10.1097/MEG.0b013e32830dfcca.
Recent reports suggest that adipokines are potent modulators of inflammation. We tested the hypothesis that the decreased food intake and the acute liver disease might be associated with changes of serum ghrelin, adipokines and insulin levels.
Fasting ghrelin, adiponectin, leptin, resistin and insulin were measured in 25 children suffering from acute viral hepatitis, caused by either hepatitis A or Epstein-Barr viruses. The age of the patients ranged from 2.2 to 17.2 years (mean: 10.4 years); 10 male and 15 female. Samples for hormones and liver function tests were drawn at 08 : 00 to 09 : 00 h after an overnight fast. The first samples were collected in the morning after the day of admission, the second samples after 2 months of recovery.
Ghrelin and adiponectin levels were significantly higher during hepatitis than after recovery (831.4+/-276.44 vs. 736.21+/-274.91 pg/ml, P<0.0001; and 22.91+/-12.93 vs. 15.16+/-8.81 microg/ml, P<0.001, respectively). Adiponectin levels correlated significantly with age-specific and sex-specific body mass index-matched percentile values as well (P=0.0062). Linear regression analysis confirmed that there was a significant association of changes in serum ghrelin and resistin levels and the severity of hepatitis (P=0.005; P<0.05). We could verify a marginal relationship of the changes of serum leptin and the severity of the disease (P=0.0646).
This study confirms that there are significant changes in serum levels of ghrelin, and adipokines in disease-associated malnutrition and acute hepatitis.
最近的报告表明，脂肪因子是炎症的有效调节剂。我们验证了以下假说，即食物摄入减少和急性肝病可能与血清 ghrelin、脂肪因子和胰岛素水平的变化有关。
测量 25 例急性病毒性肝炎（由甲型肝炎或 EBV 病毒引起）患儿的空腹 ghrelin、脂联素、瘦素、抵抗素和胰岛素。患者年龄为 2.2 至 17.2 岁（平均 10.4 岁）；男 10 例，女 15 例。激素和肝功能测试样本于入院后次日 08:00 至 09:00 空腹采集。第一次样本在入院后第一天早上采集，第二次样本在恢复后 2 个月采集。
ghrelin 和脂联素水平在肝炎期间显著高于恢复期（831.4+/-276.44 比 736.21+/-274.91 pg/ml，P<0.0001；22.91+/-12.93 比 15.16+/-8.81 microg/ml，P<0.001）。脂联素水平与年龄和性别特异性 BMI 百分位数也有显著相关性（P=0.0062）。线性回归分析证实，血清 ghrelin 和抵抗素水平的变化与肝炎严重程度显著相关（P=0.005；P<0.05）。我们可以验证血清 leptin 变化与疾病严重程度的边缘关系（P=0.0646）。
本研究证实，在疾病相关营养不良和急性肝炎中，血清 ghrelin 和脂肪因子水平存在显著变化。
