Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
Nat Rev Urol. 2009 Apr;6(4):223-7. doi: 10.1038/nrurol.2009.26.
A 48-year-old, previously healthy man presented to his local urologist with several small, violaceous, indurated lesions along the shaft of his penis and glans, which caused discomfort and penile curvature. Four weeks previously, the lesions were three small painless blemishes. Peyronie disease was initially diagnosed, but the disease progressed despite steroid treatment. Following the results of a biopsy, multifocal angiosarcoma was diagnosed. CT of the chest, abdomen and pelvis was negative for metastatic disease. At this point the patient was referred to a specialist oncology center for further management.
At the specialty center, the patient underwent physical examination, additional excisional biopsies, and Pet-ct.
Penile epithelioid hemangioendothelioma, which is a multifocal, atypical epithelioid vascular tumor.
Single-agent chemotherapy using liposomal doxorubicin hydrochloride for eight cycles, followed by 63 Gy of adjuvant external beam radiation therapy to the penis fractionated over 35 treatments.
一名 48 岁、既往健康的男性因阴茎和龟头沿阴茎干出现多个小的、紫红色、硬结性皮损而就诊于当地泌尿科医生，这些皮损导致不适和阴茎弯曲。四周前，皮损为三个小的无痛性瑕疵。最初诊断为 Peyronie 病，但尽管使用类固醇治疗，疾病仍在进展。活检结果提示多灶性血管肉瘤。胸部、腹部和骨盆 CT 检查未见转移性疾病。此时，患者被转介至专门的肿瘤中心进行进一步治疗。
在专科中心，患者接受了体格检查、额外的切除活检和 Pet-ct 检查。
阴茎上皮样血管内皮瘤，为多灶性、非典型上皮样血管肿瘤。
使用盐酸多柔比星脂质体进行单药化疗 8 个周期，随后对阴茎进行 63 Gy 的辅助外照射放疗，共 35 次分割。
