Stoquart-Elsankari Souraya, Lehmann Pierre, Villette Agnès, Czosnyka Marek, Meyer Marc-Etienne, Deramond Hervé, Balédent Olivier
Department of Imaging and Biophysics, Amiens University Hospital, Amiens Cedex, France.
J Cereb Blood Flow Metab. 2009 Jun;29(6):1208-15. doi: 10.1038/jcbfm.2009.29. Epub 2009 Apr 8.
Although crucial in regulating intracranial hydrodynamics, the cerebral venous system has been rarely studied because of its structural complexity and individual variations. The purpose of our study was to evaluate the organization of cerebral venous system in healthy adults. Phase-contrast magnetic resonance imaging (PC-MRI) was performed in 18 healthy volunteers, in the supine position. Venous, arterial, and cerebrospinal fluid (CSF) flows were calculated. We found heterogeneous individual venous flows and variable side dominance in paired veins and sinuses. In some participants, the accessory epidural drainage preponderated over the habitually dominant jugular outflow. The PC-MRI enabled measurements of venous flows in superior sagittal (SSS), SRS (straight), and TS (transverse) sinuses with excellent detection rates. Pulsatility index for both intracranial (SSS) and cervical (mainly jugular) levels showed a significant increase in pulsatile blood flow in jugular veins as compared with that in SSS. Mean cervical and cerebral arterial blood flows were 714+/-124 and 649+/-178 mL/min, respectively. Cerebrospinal fluid aqueductal and cervical stroke volumes were 41+/-22 and 460+/-149 microL, respectively. Our results emphasize the variability of venous drainage for side dominance and jugular/epidural organization. The pulsatility of venous outflow and the role it plays in the regulation of intracranial pressure require further investigation.
尽管脑静脉系统在调节颅内流体动力学方面至关重要，但由于其结构复杂性和个体差异，对其研究甚少。我们研究的目的是评估健康成年人脑静脉系统的结构。对18名健康志愿者仰卧位进行相位对比磁共振成像（PC-MRI）。计算静脉、动脉和脑脊液（CSF）流量。我们发现个体静脉血流存在异质性，成对静脉和静脉窦的优势侧各不相同。在一些参与者中，硬膜外辅助引流比通常占主导的颈静脉流出更为显著。PC-MRI能够测量上矢状窦（SSS）、直窦（SRS）和横窦（TS）的静脉血流，检测率极高。颅内（SSS）和颈部（主要是颈静脉）水平的搏动指数显示，颈静脉的搏动血流比SSS中的显著增加。颈部和脑动脉平均血流量分别为714±124和649±178 mL/min。脑脊液导水管和颈部的每搏输出量分别为41±22和460±149 μL。我们的结果强调了静脉引流在优势侧和颈静脉/硬膜外结构方面的变异性。静脉流出的搏动性及其在颅内压调节中的作用需要进一步研究。
