Department of Medical Imaging, John Hunter Hospital, Locked Bag 1, Newcastle Region Mail Center, Newcastle, NSW, 2310, Australia.
Newcastle University Faculty of Health, Callaghan Campus, Newcastle, NSW, Australia.
Fluids Barriers CNS. 2023 Aug 23;20(1):63. doi: 10.1186/s12987-023-00465-w.
The literature regarding the global cerebral blood flow (CBF) in idiopathic intracranial hypertension (IIH) is divergent leading to skepticism about the significance of blood flow to the disease's underlying pathophysiology.
The purpose of the current paper is to perform a PRISMA scoping review of the literature describing the CBF in IIH. The review investigated the PUBMED and Scopus data bases looking at case mix, technique and the methodologies employed by the studies selected.
Many studies indicate that the flow in IIH is normal but others show the flow to be altered. These later studies show a range of flows from a reduction of 20% to an increase of 50% compared to control values. Obesity is a common finding in IIH and is known to reduce CBF, anemia occurs in approximately 20% of IIH patients and is a potent cause of an increased CBF. Thus, variations in case mix may have a significant effect on the final outcome in those studies which are underpowered. The varying techniques which have been used to estimate CBF have differing strengths and weaknesses which may also have a bearing on the outcome. Some papers have significant confounding methodological issues.
This review suggests each of the variables investigated are responsible for the divergent CBF findings in IIH.
特发性颅内高压（IIH）的全球脑血流（CBF）文献存在分歧，导致人们对血流对疾病潜在病理生理学意义的质疑。
本研究旨在对描述 IIH 中 CBF 的文献进行 PRISMA 范围综述。该综述调查了 PUBMED 和 Scopus 数据库，研究了所选研究的病例组合、技术和所采用的方法。
许多研究表明 IIH 中的血流是正常的，但也有研究表明血流发生了改变。这些后续研究显示，与对照值相比，IIH 患者的血流范围从减少 20%到增加 50%不等。肥胖是 IIH 的常见发现，已知会降低 CBF，约 20%的 IIH 患者出现贫血，是增加 CBF 的一个有力原因。因此，病例组合的变化可能会对那些研究结果产生显著影响，这些研究结果的效力不足。用于估计 CBF 的不同技术具有不同的优缺点，这也可能对结果产生影响。一些论文存在严重的混杂方法学问题。
本综述表明，所研究的每个变量都可能导致 IIH 中 CBF 结果的差异。
