Lorenzana Luciano, Lankaranian Dara, Dugar Jyoti, Mayer Jason, Palejwala Neal, Kulkarni Kaushal, Warrian Kevin, Boghara Zarana, Richman Jesse, Wizov Sheryl, Spaeth George, Almodin Juliana
Glaucoma Research Center, Wills Eye Institute of Jefferson Medical College, Philadelphia, PA 9107, USA.
Ophthalmic Epidemiol. 2009 Mar-Apr;16(2):107-14. doi: 10.1080/09286580902738142.
To describe study protocol and baseline characteristics of initial subjects.
Prospective study of 194 glaucoma patients. After informed consent, patients were evaluated using a third-generation, performance-based measure, Assessment of Disability Related to Vision (ADREV), nine tasks to simulate daily living activities; including: reading in reduced illumination, recognizing facial expression, detecting motion, recognizing street signs, locating objects, ambulating, placing pegs into different sized holes, telephoning, and matching socks. All patients completed clinical tests including visual acuity (Early Treatment Diabetic Retinopathy Study [ETDRS]), monocular and binocular visual fields, contrast sensitivity, stereopsis, and National Eye Institute's Visual Functioning Questionnaire (NEI VFQ-25). Main outcome measures are scores on subtests, total scores of ADREV and NEI VFQ-25.
Mean age was 67.1 years; 51% were female, 55% were of European extraction. Seventy-two percent had open-angle glaucoma. Visual acuity (logMAR) ranged from -0.18 to 2.20, visual field mean defect ranged from -32.68 to 2.62, Binocular field score ranged from 5 to 100 and contrast sensitivity score ranged from 0 to 1.8. While ADREV score ranges from 0 (total disability) to 63 (no disability), total ADREV score ranged from 3.0 to 61.7. Total NEI VFQ-25 score ranged from 17.8 (low score indicates incapable) to 100 (high score indicates not hindered).
Methodology of this study should provide information about disability caused by visual loss, specifically glaucoma, how difficulties in performing activities relate to standard clinical tests, and how they correlate to quality of life from patient's point of view. Subsequent papers will delineate findings and discuss their application.
描述初始受试者的研究方案和基线特征。
对194例青光眼患者进行前瞻性研究。在获得知情同意后，使用基于表现的第三代视力相关残疾评估（ADREV）对患者进行评估，该评估包含九项模拟日常生活活动的任务，包括：在低光照条件下阅读、识别面部表情、检测运动、识别路标、定位物体、行走、将钉子插入不同尺寸的孔中、打电话以及配对袜子。所有患者均完成了包括视力（早期糖尿病视网膜病变研究[ETDRS]）、单眼和双眼视野、对比敏感度、立体视觉以及美国国立眼科研究所视觉功能问卷（NEI VFQ - 25）在内的临床测试。主要结局指标为各子测试得分、ADREV总分以及NEI VFQ - 25总分。
平均年龄为67.1岁；51%为女性，55%为欧洲裔。72%患有开角型青光眼。视力（logMAR）范围为 - 0.18至2.20，视野平均缺损范围为 - 32.68至2.62，双眼视野得分范围为5至100，对比敏感度得分范围为0至1.8。ADREV得分范围为0（完全残疾）至63（无残疾），ADREV总分范围为3.0至61.7。NEI VFQ - 25总分范围为17.8（低分表示无能力）至100（高分表示未受阻碍）。
本研究方法应能提供有关视力丧失（特别是青光眼）所致残疾的信息，具体说明进行活动时的困难与标准临床测试之间的关系，以及从患者角度看这些困难与生活质量的相关性。后续论文将阐述研究结果并讨论其应用。
