School of Medicine, University of Melbourne, Melbourne, Victoria, Australia.
Ophthalmology Department, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia.
Transl Vis Sci Technol. 2020 Nov 3;9(12):9. doi: 10.1167/tvst.9.12.9. eCollection 2020 Nov.
We aimed to develop and evaluate the Computerized Glaucoma Visual Function Test (CoGVFT), among a cohort of glaucoma patients, and identify potential new items to optimize the test.
A cross-sectional study involving 84 patients with open-angle glaucoma of varying severity and 18 controls without glaucoma were recruited. Better and worse eye visual field parameters, visual acuity, contrast sensitivity, 6-Part Cognitive Impairment Test (6CIT) and Glaucoma Activity Limitation-9 (GAL-9) questionnaire responses were recorded. The CoGVFT was administered to all participants. Rasch analysis was used to assess the psychometric properties of the CoGVFT, which was then evaluated with criterion, convergent, and divergent validity tests. Regression modeling determined factors predictive of CoGVFT performance.
The 38-item CoGVFT demonstrated convergent validity with statistically significant differences in glaucoma severity groups ( < 0.001, analysis of variance). The correlation coefficient for CoGVFT person measures (logits) with GAL-9 person measures (logits) and better eye (BE) mean deviation was 0.528 ( < 0.001) and 0.762 ( < 0.001), respectively, demonstrating convergent validity. Divergent validity was suboptimal as the 6CIT score demonstrated moderate correlation ( = 0.463, < 0.001) with CoGVFT person measures (logits). Multivariable analysis revealed that better BE contrast sensitivity, lower age, and better BE visual acuity were associated with better CoGVFT performance ( < 0.001).
The CoGVFT retains most of the features of its predecessor to estimate vision-based activity limitation related to glaucoma.
The CoGVFT is an easily accessible tool that can potentially be used in the community to help detect undiagnosed glaucoma in the population.
我们旨在开发和评估计算机化青光眼视觉功能测试（CoGVFT），并在青光眼患者队列中识别潜在的新项目以优化该测试。
这项横断面研究纳入了 84 名不同严重程度的开角型青光眼患者和 18 名无青光眼对照者。记录了较好眼和较差眼的视野参数、视力、对比敏感度、6 部分认知障碍测试（6CIT）和青光眼活动限制-9（GAL-9）问卷的反应。所有参与者都接受了 CoGVFT 测试。采用 Rasch 分析评估 CoGVFT 的心理测量特性，并进行了标准、收敛和发散有效性测试。回归模型确定了预测 CoGVFT 表现的因素。
38 项的 CoGVFT 具有与青光眼严重程度组显著不同的收敛有效性（<0.001，方差分析）。CoGVFT 个体测量（对数）与 GAL-9 个体测量（对数）和较好眼（BE）平均偏差的相关系数分别为 0.528（<0.001）和 0.762（<0.001），显示出收敛有效性。发散有效性不理想，6CIT 评分与 CoGVFT 个体测量（对数）呈中度相关（=0.463，<0.001）。多变量分析显示，BE 对比敏感度较好、年龄较低和 BE 视力较好与 CoGVFT 表现较好相关（<0.001）。
CoGVFT 保留了其前身的大部分特征，用于估计与青光眼相关的基于视力的活动限制。
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