Sternberg K
Universität Rostock, Institut für Biomedizinische Technik,
Laryngorhinootologie. 2009 May;88 Suppl 1:S1-11. doi: 10.1055/s-0028-1119565. Epub 2009 Apr 7.
In recent years the ear, nose and throat medicine (ENT medicine) has been stimulated by numerous innovations in the field of implants which are based on new biomaterials and modern implant technologies. In this context, biomaterials integrated in living organisms have to allow for the technical requirements and the biological interactions between the implant and the tissue. With regard to their suitability, functional capability of the implant, which is complementary to the mechanical implant properties, sufficient stability against physiological media, as well as high biocompatibility are to be demanded. Another purpose of the use of biomaterials is the maintenance and the enhancement of biofunctionality over a long time period. These general requirements for biomaterials also have their validity in ENT medicine. Different materials are applied as biomaterials. Metals belong to the oldest biomaterials. In addition, alloys, ceramics, inorganic glasses and composites were tested. Furthermore, natural and synthetic polymers, which are primarily presented in this article regarding their properties and their applications as materials for cochlear implants, osteosynthesis implants, stents and novel scaffolds for tissue engineering, are increasingly applied. According to their use in permanent and temporary implants, polymers are to be differentiated between biostable and biodegradable polymers. The presented general and current requirements for biomaterials and biomaterial applications in ENT medicine demonstrate key aspects of the current biomaterial research in this field. They do as well document the high impact of the interdisciplinary collaboration of natural and medical scientists and engineers.
近年来,耳鼻喉医学(ENT医学)受到了植入物领域众多创新的推动,这些创新基于新型生物材料和现代植入技术。在这种背景下,整合到生物体中的生物材料必须满足技术要求以及植入物与组织之间的生物相互作用。就其适用性而言,植入物的功能能力(这与植入物的机械性能相辅相成)、对生理介质的足够稳定性以及高生物相容性都是需要满足的要求。使用生物材料的另一个目的是在长时间内维持和增强生物功能。生物材料的这些一般要求在耳鼻喉医学中同样适用。不同的材料被用作生物材料。金属属于最古老的生物材料。此外,合金、陶瓷、无机玻璃和复合材料也经过了测试。此外,天然和合成聚合物作为耳蜗植入物、骨合成植入物、支架以及用于组织工程的新型支架材料,因其性能和应用在本文中主要进行了阐述,并且越来越多地被应用。根据聚合物在永久性和临时性植入物中的使用情况,可将其区分为生物稳定聚合物和可生物降解聚合物。本文所阐述的生物材料在耳鼻喉医学中的一般和当前要求展示了该领域当前生物材料研究的关键方面。它们也证明了自然科学家、医学科学家和工程师跨学科合作的重大影响。