Center for Biomaterial Development and Berlin-Brandenburg Center for Regenerative Therapies, Institute of Polymer Research, Helmholtz-Zentrum Geesthacht, Teltow, Germany.
Clin Hemorheol Microcirc. 2011;49(1-4):347-55. doi: 10.3233/CH-2011-1485.
Polymer-based biomaterials are extensively used in all disciplines of clinical medicine and innovations in biomaterial science are building a product pipeline, e.g., of future cardiovascular implants. Still, cardiovascular applications demand a number of extensive requirements of properties and functions to be fulfilled by the polymer matrix. This report provides an overview on some of these issues and how they can be addressed by a tailored design of novel polymer-based biomaterials. Multifunctional shape-memory polymers are highlighted as a class of materials that combine biocompatibility and the capability for stimuli-induced active movements for anchoring of implants with a controlled degradation and drug release profile to enable a functional regeneration of the tissue at the application site.
基于聚合物的生物材料在临床医学的各个领域得到了广泛的应用，生物材料科学的创新正在构建一个产品渠道，例如未来的心血管植入物。尽管如此，心血管应用仍需要聚合物基质满足许多广泛的性能和功能要求。本报告概述了其中的一些问题，以及如何通过定制设计新型基于聚合物的生物材料来解决这些问题。多功能形状记忆聚合物是一类材料的代表，它们结合了生物相容性和刺激响应性主动运动的能力，用于锚固具有可控降解和药物释放特性的植入物，从而使应用部位的组织能够实现功能再生。
