塔拉纳诺苷A - H，从渐尖叶水锦树中分离得到的8个新的木脂素苷及其对H2O2诱导的PC12细胞损伤的保护作用。

Tarennanosides A-H, eight new lignan glucosides from Tarenna attenuata and their protective effect on H2O2-induced impairment in PC12 cells.

作者信息

Yang Xian-Wen, He Hong-Ping, Du Zhi-Zhi, Liu Hai-Yang, Di Ying-Tong, Ma Yan-Lin, Wang Fang, Lin Hua, Zuo Yi-Qing, Li Ling, Hao Xiao-Jiang

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, P. R. China.

出版信息

Chem Biodivers. 2009 Apr;6(4):540-50. doi: 10.1002/cbdv.200800022.

DOI:10.1002/cbdv.200800022

PMID:19353535

Abstract

Eight new lignan glucosides, tarennanosides A-H (1-8, resp.), were isolated from the whole plant of Tarenna attenuata, together with three known compounds, fernandoside, (-)-lyoniresinol, and (-)-isolariciresinol. The planar structures of new compounds were elucidated mainly by analysis of physical and spectroscopic data, and the absolute configurations were determined by acid hydrolysis as well as CD spectroscopy. Compounds 1 and 2 exhibited potent antioxidant activities against H2O2-induced impairment in PC12 cells. Preliminary mechanism study by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) method showed that these two compounds could act as radical scavengers.

摘要

从薄叶栀子的全株中分离出8种新的木脂素苷，分别为塔拉纳诺苷A - H（1 - 8），以及3种已知化合物，费尔南多苷、（-）-里诺树脂醇和（-）-异落叶松脂醇。新化合物的平面结构主要通过物理和光谱数据分析来阐明，其绝对构型通过酸水解以及圆二色光谱确定。化合物1和2对H2O2诱导的PC12细胞损伤表现出较强的抗氧化活性。通过1,1 - 二苯基 - 2 - 苦基肼（DPPH）法进行的初步机制研究表明，这两种化合物可作为自由基清除剂。