将微滴微反应器与质谱联用：在线读取单个微滴的成分
Coupling microdroplet microreactors with mass spectrometry: reading the contents of single droplets online.
作者信息
Fidalgo Luis M, Whyte Graeme, Ruotolo Brandon T, Benesch Justin L P, Stengel Florian, Abell Chris, Robinson Carol V, Huck Wilhelm T S
机构信息
Melville laboratory for Polymer Synthesis, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, United Kingdom.
出版信息
Angew Chem Int Ed Engl. 2009;48(20):3665-8. doi: 10.1002/anie.200806103.
Fully integrated: Mass spectrometry has been integrated into a detection scheme for microdroplets that are created within microfluidic channels (see picture, scale bar 200 microm). This technique allows droplets to be identified based on the compounds they contain, and combines fluorescence screening with MS analysis. These experiments indicate how similar approaches can be applied to the ambitious goals of on-chip protein evolution and chemical synthesis.
完全集成
质谱已被集成到一种用于检测微流控通道内产生的微滴的方案中（见图，比例尺为200微米）。该技术允许根据微滴所含的化合物来识别微滴，并将荧光筛选与质谱分析相结合。这些实验表明了如何将类似方法应用于芯片上蛋白质进化和化学合成的宏伟目标。
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