慢性收缩性心力衰竭患者的血清氧化应激水平与临床参数相关。
Serum oxidative stress level correlates with clinical parameters in chronic systolic heart failure patients.
作者信息
Amir Offer, Paz Hagar, Rogowski Ori, Barshai Marina, Sagiv Moran, Shnizer Sergei, Reznick Abraham Z, Amir Ruthie E
机构信息
Department of Cardiology, Lady Davis Carmel Medical Center, Haifa, Israel.
出版信息
Clin Cardiol. 2009 Apr;32(4):199-203. doi: 10.1002/clc.20317.
BACKGROUND
Serum oxidative stress (OS) level has an important role in the inflammatory process of heart failure.
HYPOTHESIS
The study was designed to analyze serum OS levels in chronic heart failure (HF) patients and to examine the relation between OS levels and other clinical and prognostic parameters of HF.
METHODS
We studied 82 consecutive chronic symptomatic HF patients with systolic LV dysfunction (ejection fraction <45%). The serum OS level was determined using thermochemiluminescence assay. We compared the serum OS levels with patients' clinical and prognostic parameters.
RESULTS
Higher serum OS levels were associated with higher New York Heart Association class (P = .01), worse renal function (serum urea, creatinine, and creatinine clearance) (P<.001) and higher serum levels of hs-C-reactive protein and N-terminal pro brain natriuretic peptide (P = .001, P<.001, respectively).
CONCLUSIONS
In chronic systolic HF patients, high serum OS levels correlate with advanced disease and known markers of poor prognosis.
背景
血清氧化应激（OS）水平在心力衰竭的炎症过程中起重要作用。
假设
本研究旨在分析慢性心力衰竭（HF）患者的血清OS水平，并探讨OS水平与HF的其他临床及预后参数之间的关系。
方法
我们研究了82例连续的有症状的慢性收缩性HF患者，其左心室功能不全（射血分数<45%）。采用热化学发光分析法测定血清OS水平。我们将血清OS水平与患者的临床及预后参数进行了比较。
结果
较高的血清OS水平与较高的纽约心脏协会分级相关（P = 0.01），肾功能较差（血清尿素、肌酐和肌酐清除率）（P<0.001）以及较高的血清高敏C反应蛋白和N末端脑钠肽前体水平相关（分别为P = 0.001，P<0.001）。
结论
在慢性收缩性HF患者中，高血清OS水平与疾病进展及已知的不良预后标志物相关。
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