系统性红斑狼疮中的细胞因子
Cytokines in systemic lupus erythematosus.
作者信息
Lourenço Elaine V, La Cava Antonio
机构信息
Division of Rheumatology, Department of Medicine, University of California Los Angeles, Los Angeles, CA 90095-1670, USA.
出版信息
Curr Mol Med. 2009 Apr;9(3):242-54. doi: 10.2174/156652409787847263.
Abstract
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the production of autoantibodies that can form immune complexes and deposit in tissues, causing inflammation and organ damage. There is evidence that interferons and some interleukins can have an active role in the pathogenesis of SLE and can contribute significantly to the immune imbalance in the disease, whereas the role of some cytokines (such as TNF) is still debated. This review discusses the activity of several cytokines in SLE, their effects on the immune cells in relation to the disease pathogenesis, and the promise and limitations of cytokine-based therapies in clinical trials for lupus patients.
摘要
系统性红斑狼疮（SLE）是一种慢性自身免疫性疾病，其特征是产生自身抗体，这些自身抗体可形成免疫复合物并沉积在组织中，导致炎症和器官损伤。有证据表明，干扰素和一些白细胞介素在SLE的发病机制中可发挥积极作用，并可显著导致该疾病的免疫失衡，而一些细胞因子（如肿瘤坏死因子）的作用仍存在争议。本综述讨论了几种细胞因子在SLE中的活性、它们在疾病发病机制方面对免疫细胞的影响，以及基于细胞因子的疗法在狼疮患者临床试验中的前景和局限性。
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