Xiang Shate, Zhang Jingjing, Zhang Mengge, Qian Suhai, Wang Rongyun, Wang Yao, Xiang Yingshi, Ding Xinghong
School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, China.
First Clinical School of Medicine, Nanjing Medical University, Nanjing, China.
Front Pharmacol. 2022 Sep 29;13:988512. doi: 10.3389/fphar.2022.988512. eCollection 2022.
Th1 and Th2 cells and their associated cytokines function in the pathogenesis of systemic lupus erythematosus (SLE), but their exact roles are uncertain. We performed a meta-analysis to examine the relationship of these cells and cytokines with SLE. Multiple databases were searched to identify publications that reported the percentages of Th1 and Th2 cells and their associated cytokines in SLE patients and healthy controls (HCs). Meta-analysis was performed using Stata MP version 16. SLE patients had a lower percentage of Th1 cells, a higher percentage of Th2 cells, and higher levels of Th1- and Th2-associated cytokines than HCs. SLE treatments normalized some but not all of these indicators. For studies in which the proportion of females was less than 94%, the percentage of Th2 cells and the level of IL-10 were higher in patients than HCs. SLE patients who had abnormal kidney function and were younger than 30 years old had a higher proportion of Th1 cells than HCs. SLE patients more than 30 years old had a higher level of IL-6 than HCs. Medications appeared to restore the balance of Th1 cells and other disease indicators in patients with SLE. Gender and age affected the levels of Th1 and Th2 cells, and the abnormally elevated levels of Th2 cells appear to be more pronounced in older patients and males. [https://www.crd.york.ac.uk/prospero/], identifier [CRD42022296540].
辅助性T细胞1（Th1）和辅助性T细胞2（Th2）及其相关细胞因子在系统性红斑狼疮（SLE）的发病机制中发挥作用，但其确切作用尚不确定。我们进行了一项荟萃分析，以研究这些细胞和细胞因子与SLE的关系。检索了多个数据库，以确定报告SLE患者和健康对照（HC）中Th1和Th2细胞百分比及其相关细胞因子的研究。使用Stata MP 16版进行荟萃分析。与HC相比，SLE患者的Th1细胞百分比更低，Th2细胞百分比更高，Th1和Th2相关细胞因子水平更高。SLE治疗使其中一些但并非所有这些指标恢复正常。在女性比例低于94%的研究中，患者的Th2细胞百分比和白细胞介素-10（IL-10）水平高于HC。肾功能异常且年龄小于30岁的SLE患者的Th1细胞比例高于HC。年龄超过30岁的SLE患者的IL-6水平高于HC。药物似乎恢复了SLE患者Th1细胞和其他疾病指标的平衡。性别和年龄影响Th1和Th2细胞水平，Th2细胞异常升高的水平在老年患者和男性中似乎更为明显。[https://www.crd.york.ac.uk/prospero/]，标识符[CRD42022296540]
