Schroecksnadel Katharina, Fischer Birgit, Schennach Harald, Weiss Guenter, Fuchs Dietmar
Division of Biological Chemistry, Biocenter, Innsbruck Medical University, Fritz Pregl Str. 3, A-6020 Innsbruck, Austria.
Drug Metab Lett. 2007 Aug;1(3):166-71. doi: 10.2174/187231207781369816.
Inflammation is a hallmark of various diseases like infections, autoimmune syndromes, cardiovascular and neurodegenerative disorders, and cancer. Thereby, Th1-type cytokine interferon-gamma is a central pro-inflammatory mediator. Antioxidant compounds counteract the activation of T-cells and macrophages. This anti-inflammatory activity could be important for the development of immunotolerance and for treatment of above-mentioned disorders.
炎症是多种疾病的标志，如感染、自身免疫综合征、心血管和神经退行性疾病以及癌症。因此，Th1型细胞因子干扰素-γ是一种主要的促炎介质。抗氧化化合物可对抗T细胞和巨噬细胞的激活。这种抗炎活性对于免疫耐受的发展以及上述疾病的治疗可能很重要。
