Cui Liang, Chan Wan, Qiu Feng, Cai Zongwei, Yao Xinsheng
Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang 110016, China.
Drug Metab Lett. 2008 Dec;2(4):261-8. doi: 10.2174/187231208786734148.
Andrographolide is a component of a famous traditional Chinese herbal medicine Andrographis paniculate (Burm) Nees. In this study, the metabolites of andrographolide in human urine after oral administration were investigated. Four urea adducts were isolated by chromatography methods and identified by high-resolution mass spectra, 1 D and 2D NMR spectroscopy.
穿心莲内酯是著名的传统中药穿心莲（爵床科植物）的一种成分。在本研究中，对口服给药后人体尿液中穿心莲内酯的代谢产物进行了研究。通过色谱方法分离出四种尿素加合物，并通过高分辨率质谱、一维和二维核磁共振光谱进行鉴定。
