Ahmad Shamweel, Al-Juaid Nami Fawazan, Alenzi Faris Q, Mattar Essam H, Bakheet Osama El-Sayed
Department of Clinical Microbiology/Immunology, College of Medical Sciences, King Saud University, Kingdom of Saudi Arabia.
J Coll Physicians Surg Pak. 2009 Apr;19(4):264-5.
The aim of this descriptive study was to determine the prevalence of Klebsiella pneumoniae from different clinical specimens, their antibiotic susceptibility pattern and the extended-spectrum beta-lactamase (ESBL) production among such isolates at Armed Forces Hospital, Al-Kharaj, Saudi Arabia, from November, 2004 to October, 2007. A total of 328 isolates of K. pneumoniae recovered from 8152 different specimens were studied for ESBL production and antimicrobial susceptibility. The prevalence of K. pneumoniae was 4% (328/8152). We observed a high percentage of K. pneumoniae resistant to ampicillin (100%) and tetracycline (92%). The prevalence of ESBL-producing K. pneumoniae was found to be 10.4% (34/328). The ESBL-producing strains were mostly from aspirates (25%) followed by sputum (20%) and blood (18.2%). These ESBLproducing isolates were highly resistant to gentamicin and ciprofloxacin. All isolates were susceptible to imipenem. Our findings demonstrate a high percentage of ESBL-producers among clinical isolates of K. pneumoniae and a high rate of multidrug resistance. Continued infection control measures and prudent use of antimicrobial agents are essential in reducing the spread of multi-resistant ESBL-producing K. pneumoniae.
这项描述性研究的目的是确定2004年11月至2007年10月在沙特阿拉伯海拉杰武装部队医院不同临床标本中肺炎克雷伯菌的流行情况、其抗生素敏感性模式以及此类分离株中产超广谱β-内酰胺酶（ESBL）的情况。对从8152份不同标本中分离出的328株肺炎克雷伯菌进行了ESBL产生情况和抗菌药物敏感性研究。肺炎克雷伯菌的流行率为4%（328/8152）。我们观察到肺炎克雷伯菌对氨苄西林（100%）和四环素（92%）的耐药率很高。产ESBL的肺炎克雷伯菌的流行率为10.4%（34/328）。产ESBL菌株大多来自吸出物（25%），其次是痰液（20%）和血液（18.2%）。这些产ESBL的分离株对庆大霉素和环丙沙星高度耐药。所有分离株对亚胺培南敏感。我们的研究结果表明，肺炎克雷伯菌临床分离株中产ESBL的比例很高，且多重耐药率很高。持续的感染控制措施和谨慎使用抗菌药物对于减少多重耐药产ESBL肺炎克雷伯菌的传播至关重要。
